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The estrogen may help reduce the effects of the androgens. Treatment of spasms from rheumatic disorders, stroke, cerebral palsy and Parkinson disease; use of intrathecal form via IV, IM, SC, or epidural routes. If you need to take them for a long period of time then you should pay your doctor regular visits in order to professionally monitor your condition and make sure that the drugs aren't causing any harmful effects. With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed. The progressive degeneration of the motor neurons in ALS eventually lead to their death.